Antioxidant and hepatoprotective activities of ethanolic. The cytotoxic activity of the extracts of cocculus hirsutus on mcf7 cells was investigated in vitro through mtt assay. Synthesis function protein, carbohydrate and lipid metabolism. Hepatoprotective activity of three vegetable peel extracts. Studies on hepatoprotective activity of hydroalcoholic leaf extract of pongamia pinnata against ir induced hepatic reperfusion injury saiprasanna behera1, s. The present study was carried out to screen and evaluate the hepatoprotective activity of leaf extracts of aegle marmelos l. Hepatoprotective activity of medicinal plants thesis proposal. The goal of the present study was to examine the antioxidant and hepatoprotective activity of some medicinal. Silymarin is a natural compound that is present in species of silybum marianum commonly known as milk thistle. The use of plant compounds to treat infection is an age. The hepatoprotective activity of the leaf extracts may be due to the free radical scavenging and antioxidant activity, resulting from the presence of some phenolic compounds in the extracts. The potential of peel extracts from three vegetables such as artocarpus heterophyllus jack fruit, colocasia esculenta taro and cucurbita pepo pumpkin was evaluated for invitro inhibition of ferric chloride fecl3 induced hepatic lipidperoxidation lpo.
Medicinal plants having hepatoprotective activity s. Therefore, it is quite interesting to investigate the hepatoprotective effect of t. Synergistic hepatoprotective potential of ethanolic extract of. Alianthus exelssa, hepatoprotective activity, carbon tetrachloride. One of the major source of natural products are plants. The genus amaranthus has potential activity as a hepatoprotective agent. A number of studies have shown that the plant extracts having antioxidant activity protect against ccl 4 hepatotoxicity by inhibiting lipid peroxidation and enhancing antioxidant enzyme activity 45, 42, 21, 24,46 and38. The present investigation is aimed to evaluate the hepatoprotective effects of citrus hystrix and citrus maxima red and white variety methanolic leaf extracts on paracetamol induced toxicity.
About 600 commercial herbal formulations with hepatoprotective activity. All the plant extracts were screened for their antimicrobial activity. Antioxidant and in vitro cytotoxic activity of extracts of. There are many plants and their extracts that have been shown to possess. Herbal medicines have been used extensively for decades for the treatment of many diseases. Antimicrobial assay the antimicrobial activity of the plant extracts was evaluated using agar well diffusion method 21 with minor modifications. Hepatoprotective activity of the medicinal plants name of plant source or family plant parts used hepatotoxic inducing agents extracts studied biochemical and histopathological parameters studied boerhaavia diffusa. Pdf medicinal plants possessed hepatoprotective activity. Parmar and others published hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in wistar rats find, read and cite all the. Antibacterial activity of plant extracts 247 brazilian journal of microbiology 2000 31.
Roja ramani3, prasanta kumar choudhury1 1,1department of pharmacology, royal college of pharmacy and health sciences, berhampur, odisha 760002. In this study we further verified the hepatoprotective activity through serum analysis. The extracts exhibited significant antioxidant property as evident by the trolox values and effective scavenging of dpph and. Hepatoprotective activities of ethanolic and aqueous extracts of a. The liver is one of the few organs of highly specialized function whose cells can. The hepatoprotective effect of the extract of the stem of the plant 200600 mgkg was evaluated by the assay of liver function parameters, namely total and direct bilirubin, serum protein and albumin, total cholesterol, alanine aminotransaminase alt, aspartate aminotransaminase ast, and alkaline phosphatase activities alp, antioxidant enzymes like superoxide dismutase sod, catalase cat, and glutathione peroxidase gpx, reduced glutathione gsh and histopathological study of the. The results of antimicrobial activity showed that water and ethanol crude extracts were active on all the strains of pathogens tested at different concentrations, with ethanol extracts exerting more activity. The hepatoprotective activities of dried whole plant of chenopodium album linn, acetone and methanol extracts in ratio of 50. Introduction in ancient indian literature, it is mentioned that every plant on this earth is useful for human beings, animals and other plants. Recent experience has shown that plant drugs are nontoxic, safe and even free from side effects 4.
The methanolic extracts, comparable to silymarin as a conventional drug, exhibited a higher hepatoprotective activity. The present study was done to evaluate the hepatoprotective and the in vivo antioxidant activity of ethanolic extracts of leaves of the plant in carbon tetrachlorideinduced liver damage in rats. Hence, it will be appropriate to combine these models. Hepatoprotective potential of malvaviscus arboreus against. These free radicals combine with cellular proteins. In the present study s the possible hepatoprotective potentials of the aqueous extract of the leaves of hyptis suaveolens was. In an attempt to further establish the pharmacological properties of bauhinia purpurea fabaceae, hepatoprotective potential of methanol extract of b. Hepatoprotective potential of some local medicinal plants.
Histopathologic examination assured the hepatoprotective activity of the extracts. Michael atef fawzy, john refaat fahim, samar yehia. No name of plant family part used extract animal model hepatotoxic agent used remark ref. Hepatoprotective plantsandrographis lineata neeshepatoprotective effect of andrographis lineata acanthaceae extracts in ccl4. Hepatoprotective and antioxidant activity of tragia. Investigations on hepatoprotective activity of leaf. An oral administration of the methanol extract 60 mgkg significantly reduced p pdf split merge on.
Hepatoprotective activity of aqueous extract of the leaves. In vitro antioxidant activity and hepatoprotective. A methanolic extract of cichorium intybus has shown hepatoprotective activity against acetaminopheninduced liver damage. A recent update on hepatoprotective potential of herbal plant mohammad irfan ali1 and manoj kumar2 1school of sciences, suresh gyan vihar university, jaipur302017, rajasthan, india 2marine biotechnology laboratory, department of botany, university of delhi, north campus, india corresponding authoremail. Pdf hepatoprotective activity of six polyherbal formulations in. Hepatoprotective effect of leaf extracts from citrus. Leaf extracts were given in the dose of 200 mgkg body weight for 7 days and toxicity was induced by paracetamol 2 gkg on day 5.
Hepatoprotective activity of some medicinal plants in sudan hindawi. Hence, the present study focused on evaluating the potential in vitro. Further studies are in progress to better understand the mechanism of action of the plant extracts responsible for the observed hepatoprotective activity. Plants contain active constituents known as phytochemicals, which have been tested for their hepatoprotective potential in many parts of the world. Hepatoprotective activity of the extract of homalium letestui stem. Phd thesis on hepatoprotective activity, essay cost. Pdf hepatoprotective activity of some plants extract. Antioxidant activity of the plant extracts were characterized by using dpph free radical scavenging method. Hepatoprotective activity of some indigenous plants. The present pharmacological investigation focuses on evaluation of the efficacy of aqueous extract of roots of amaranthus tricolor linn. Studies on some plant extracts for their antimicrobial. Hepatoprotective activity of some medicinal plants in sudan ncbi. Melia azedarach, hepatoprotective activity, simvastatin, ethanol and silymarin.
Therefore, a supplementation with plant products is an excellent natural support especially if you are facing a pharmacological therapy. Hepatoprotective role of extracts of momordica char antia in acetaminopheninduced t oxicity in rabbits. Sgpt, sgot, alp bilirubin and total protein were measured. The liver is the key organ regulating homeostasis in the. Manisha 1, suresh babu sayana 2 and rajesh pal 1 department of pharmacology, v.
Page 62 of 250 intybus extracts on liver cells due to the presence of flavonoids and their antioxidant effects. The plant material was defatted with nhexane and 70% methanol, respectively. Hepatoprotective activity of the extract of homalium. This may indicate that the plant extracts contain compounds, which can remove toxic metabolites following tbh induced toxicity.
There are many plants and traditional formulations available to treat the liver diseases 5, 6. Pdf hepatoprotective activity of methanolic extract of oldenlandia. Sitha institute of pharmaceutical sciences 2, hyderabad. Medicinal plants with hepatoprotective activity in iranian. These are traditionally treated by medicinal plants especially in rural areas. Hepatoprotective effect of aqueous extracts of some. Thus the extracts ofalianthus exelssa could afford significant dosedependent protection against ccl 4 induced hepatocellular injury. While some plant extracts were comparatively more effective against all the three pathogens xanthomonas campestris, agrobacterium rhizogenes and aspergillus fumigatus. In our research, we decided to demonstrate that peptides isolated from anethum graveolens l. Indian herbal medicines in the treatment of liver diseases.
Carbon tetrachloride, hepatoprotection, paracetamol, psidium guajava, thioacetamide liver diseases, such as jaundice, cirrhosis and fatty liver are very common worldwide. Five groups of rats were used and administered orally once daily with 10% dmso negative control, 200 mgkg. Hepatoprotective activity of ethanolic extract of salix subserrata. Throughout sudans long history, local indigenous cultures have merged with many other cultures such as pharaonic, christian, and islamic. In india, numerous medicinal plants are used for the treatment of liver disorders. The hepatoprotective activity was assessed using liver functional test, oxidative. Pdf the present study is to evaluate the hepatoprotective activity of methanolic. In this study, we report hepatoprotective activity of this plant against paracetamol induced liver injury in order to provide scientific basis for its use in traditional. Hepatoprotective activity of methanolic extract of. The hepatoprotective activities of the total extract and its derived. Hepatoprotective activity of some medicinal plants in sudan. A recent update on hepatoprotective potential of herbal plant. Mohammed ishaq 3 deccan school of pharmacy 1, hyderabad, andhra pradesh, india.